RESET

RESET was a clinical, entirely non-interventional registry focused on the collection of clinical data with the aim of mapping the incidence, prevalence, morbidity and mortality in patients with sellar expansions.

RESET was a registry of selected clinical centres which participated in the project on a voluntary basis. The project had been initiated in 2008 and was coordinated by the General University Hospital in Prague.

The project was based on the collection of data for clearly defined clinical hypotheses. At the first stage, it was not aimed at the collection of representative epidemiological data; rather, it aimed to monitor clinically well-defined groups of patients.

The RESET project was prepared as an entirely non-interventional registry which focused on both retrospective and prospective collection of clinical data. Retrospective comparisons were performed either within longitudinal time monitoring or on the “case-control” principle.

In clearly-defined groups of patients, the registry monitored the entire progression over time – from diagnostic data to therapy results with a subsequent long-time monitoring with annual updates (“follow-up”). Apart from followed-up and newly-diagnosed patients, basic data on previously-treated and already deceased patients were recorded into the registry as well. In this way, the registry enabled an effective assessment of mortality and survival parameters.

Click on one of the following links to learn more about:

• project objectives
• key hypotheses and subprojects

Other important information:

• Expert guarantor: Prof Vaclav Hana, MD (expert guarantor for the Czech Republic), Peter Vanuga, MD, PhD (expert guarantor for Slovakia)
• Funding: Novartis Ltd.
• Partners: 9 specialized centres in the Czech Republic and Slovakia (you can find more detailed information on the website of the RESET project)
• Brief overview of results: you can find more detailed information on the website of the RESET project