FIND

Opportunistic fungal infections are a dreaded complication in haemato-oncological patients. Patients with acute leukaemia are most at risk. The most common fungal invasive infections involve candidiasis (most frequently caused by Candida albicans) and aspergillosis. An appropriate diagnosis and treatment of opportunistic infections is therefore of key importance in the comprehensive care provided to these patients. Optimisation of diagnostic and therapeutic procedures can be achieved by a detailed monitoring and evaluation of diagnostic procedures and treatment outcomes in patients with invasive mycoses.

The FIND project belongs to a group of projects solved in cooperation between the Institute of Biostatistics and Analyses and the CELL group. IBA MU provides the technical solution of the registry and data analysis.

Primary objectives of the project:

• to collect data on patients diagnosed with invasive aspergillosis, invasive candidiasis, and rare invasive fungal infection,
• to monitor the epidemiology, therapy, and treatment outcomes in haemato-oncological patients in which antimycotic therapy has been administered.

Secondary objectives of the project:

• to standardise the diagnostic and therapeutic procedures in haemato-oncological patients,
• to define prognostic factors in relation to the treatment of choice,
• to define optimal therapy in individual haemato-oncological diagnoses,
• to standardise treatment procedures in haemato-oncological diagnoses,
• to evaluate the economic costs of treatment of hemato-oncological patients,
• to develop and publish methodical materials leading to the standardisation of medical records, and to the evaluation of treatment outcomes in this diagnostic group; the documentation might be subsequently used in other areas of cancer care.

Other important information:

• Expert guarantors: Prof. Jiří Mayer, MD, PhD; Prof. Zdeněk Ráčil, MD, PhD
• Partners: large haemato-oncological centres in the Czech Republic